Nanoduct®
Neonatal Sweat Analysis System
Early diagnosis and treatment can significantly improve both the quality of life and the lifespan of children born with cystic fibrosis. The proven diagnostic effectiveness of analyzing electrolyte concentration in sweat makes it vital to perform this test as soon as possible after birth.
ELITech-Wescor has long been the leading innovator in the laboratory diagnosis of cystic fibrosis® with the Macroduct Sweat Collector and its companion, the Sweat-Chek™ Sweat Conductivity Analyzer.
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GROUND BREAKING INNOVATION BASED ON PROVEN TECHNOLOGY
The Nanoduct Neonatal Sweat Analysis System combines and miniaturizes the proven collection and analysis technologies of Macroduct and Sweat-Chek to accommodate the tiny limbs of newborn infants, and provides reliable laboratory diagnosis of CF as soon as a newborn’s sweat glands are capable of producing sweat.
Innovative features of the Nanoduct System include the special electrode/sensor holders that are positioned on the patient’s limb before iontophoresis. The holders make electrode placement simple and secure. They also guarantee that the sensor collecting surface is perfectly registered with the stimulated skin area and attachment pressure is optimal when the sensor is attached.
Nanoduct incorporates the classic method of inducing sweat by pilocarpine iontophoresis. The pilocarpine is carried into the dermis of
the patient from improved Pilogel® Iontophoretic Discs by a controlled DC electric current supplied by the Nanoduct System.
This is followed by continuous flow analysis of sweat electrolyte concentration using the unique conductivity sensor. Electrodes and the sensor are connected to the Nanoduct System via a single control cable.
The Nanoduct Neonatal Sweat Analysis System simplifies the sweat test and for the first time makes possible reliable laboratory diagnosis of CF in the first days of life.
CONTINUOUS-FLOW ANALYSIS OF ELECTROLYTE CONTENT
When the sensor is attached to the patient, the stimulated sweat emerging from the sweat glands is anaerobically directed into a microconductivity cell within the sensor. This provides a continuous display of the electrical
conductivity in the freshly emerged sweat. Conductivity has been shown to be the equal of chloride in its ability to discriminate diagnostically between CF and non-CF subjects.
SEPARATE COLLECTION PHASE IS ELIMINATED
Continuous-flow analysis while the sensor is on the limb, eliminates potential handling errors, saves laboratory time, and ensures accuracy by providing virtually infinite replications of the analysis on freshly excreted sweat. A further benefit: any inadvertent contamination of the sensor collecting surface will be dissipated before the final reading is displayed.
IMPROVED PILOGEL DISCS®
- Increased pilocarpine concentration
- Iontophoresis time reduced to only 2.5 minutes
- Buffered to prevent pH changes
